these are meperidine drugs with a different n-substutent this class of drugs is a very promising and potentially lucrative one.
the basic gist of it is this the n-substutent can impart potencies as much as 700 times greater than morphine and, they are easily made from readily available chemicals.

http://en.wikipedia.org/wiki/Phenoperidine

the ketone is actually of greater potency than the secondary alcohol this means fewer steps.
the 2-propiophenone of demerol for example is 60-200 times the potency of demerol; using a reversed ester the potency climbs 20 times that, as a rule.
these are wickedly potent drugs better expirimented on others first.
for example: one could make 4-phenyl piperidine-4-ol and n- substitute it by means of a mannich reaction with acetophenone and formaldehyde
the piperidinol itself can be made from alpha-methyl styrene formaldehyde and ammonium chloride.
yeilds are lousy so it's wiser to make the oxazine then make the phenyl 1,3,5,6 tetrahydropyridine and hydrobrominate that then, react with water.
but even then the yeild is only 25%
yeilds  are 12% with as per the other way.

read about them in opiod analgesics page 234

pethidine is crap you have to reverse the ester to make it worth your time.

no these type of things have to be treated with respect  (test them on people who owe you money.)
just like atara suggested.
why the world is'nt stocked with drugs like this?
simple, the cartels control these kind of things, step on thier business, you better have an army.

that was what i was talking about reversed propanoyl esters at the 4 position.
but amandatoic esters are even more potent than that.
seems i have figured out over the years how to engineer super opiods which may be my downfall, i fear.

it's an adamantyl moiety see:

http://www.scribd.com/doc/40503114/Synthesis-of-Adamantyl-Analogs-of-Analgesics-A-N-Voldeng-C-A-Bradley-R-D-Kee-E-L-King-and-F-L-Melder-Journal-of-Pharmaceutical-Science-19

i've seen it around.
also you can do this you can take piperidone react it with phenyl grignard quench with p-anhydride and n-alkylate that.
then test the ld50 (on mice of course) moneys if you can find them, even cheaper are junkies.
we don't really know the potency the propiophenone is 1/2 that of the benzylic alcohol and in humans phenoperidine is 10 times the potency of morphine
reverse the ester as a rule invreases the potency 20 fold so realistically it could be closer to 100 times stronger than morphine.
here is another patent this time in english describing the mannich reaction on nor-pethidine.

yes in fact i do pertinent question
to answer your question on the scheme the mannich reaction is performed on the 4-phenyl-4-piperidinol with paraformaldehyde and acetophenone.
this yeilds a propiophenone which is pretty good in it's own right.
then the esterification is carried out then, the ketone is reduced with nabh4.
the acetyl ester of the benzylic alcohol at carbon 3 is actually stronger than the alcohol.
i would just do this react some alpha-methylstyrene with formaldehyde and ammonium chloride.
distill off the 12% 4-phenylpiperidine-4-ol
take the remaning mixture and convert it to the tetrahydropyridine with h2so4 then  hydrobrominate that and boil it in water to get the remaining stuff.
of course for something this potent, who cares if you only get 12% from common industrial chemicals?
 

no read the paper the propionophenone is made then the piperidinol is esterified and that is a really good analgesic in it's own right.
but if you wanted to juice it up you could reduce the ketone and then esterify with acetic anhydride to make some kind of elephant tranquillizer.
the idea it to use common everyday industrial chemicals.

well there are contradictory studies some say the benzylic ester is inactive and others say it's even more active.

the propionoxy ester of the benzylic alcohol is 1500 times stronger than pethidine so that may be the way to go.
according to this reference.
found on page 238

P A J Janssen, N B Eddy, J Med Pharm Chem 2, 31 (1960)

found in the book linked above 'opiod analgesics'

of course in life it can't be that easy.


actually i spotted a problem already with that scheme.
in the triazine synthesis with formalin and the amino alcohol the aldehyde would form a ketal with the benzylic alcohol which could throw a wrench in the plans.
probably what would happen is the ketal would split up under the acid conditions of the reaction.
then the excess aldehyde would undergo a prins reaction with the styrene forming a dioxolane by-product and lower yields.

it may be possible to control the formation of the trialkyltriazine because nitrogen is a stronger nucleophile it would react faster with the aldehyde.
so the formalin could be added portionwise and with exacting stochiometry to prevent this side reaction

looks like the existance of 1,3,5 hexahydrotrialkyltrizines of amino alcohols disprooves my objection.

http://www.chemicalbook.com/ChemicalProductProperty_EN_CB0425698.htm
interesting a one step synthesis to the most powerful demerol analouge known to man.
what a possiblity.

The Aminomethylation of Styrene. A New Synthesis of 3-Amino-1-phenylpropanol
S. L. Meisel, J. J. Dickert Jr., H. D. Hartough
J. Am. Chem. Soc., 1956, 78 (18), pp 4782–4783
DOI: 10.1021/ja01599a064
Publication Date: September 1956

this is the iupac name: 3-Amino-1-phenyl-propan-1-ol

It looks like purification might be a problem, though. That di-ester is a rather large molecule, so might boil at an excessive temperature for vacuum distillation. These reversed esters decompose to the alkene if heated too strongly.