Author Topic: Lpac ----> Ephedrine  (Read 565 times)

kingnothing

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Lpac ----> Ephedrine
« on: April 14, 2012, 10:25:37 PM »
Hi there ppl.

This my first post and i hope i dont get my head blown off :)

Iv been trying to find the actual detailed Synth for turning L-pac gained from the Bio transformation fermentation process into lephedrine but cant find a decent tek to explain..!
i did a quick search on this forum and another i abandoned tonight,
i may have found something on this forum, but been awake for way to long,that i dont have time to check. 
its my greek easter and i have to go, otherwise ild be looking for hours more )
most posts talk about the actual fermentation and less about the conversion, and when i thought i found it, it turned out to be lpac---> (PPA) (i think), Im sooo tierd i cant even remember the intertwining names :(, im not usually so lazy but i seriusly been sitting here 12 hours scouting, for a conversion method,
actually i think i did find one, but not the one i was after,

I dont want to be spoon fed the info, i just thought since i made an acc here ild give the experts a chance to lay it out as clearly as possible to help me out, I saw a method i think which used palladium as a catalyst, but i want the most simple tek to start with, like i said im not an expert, i just wanna learn.
n if i cant find it im sure other haveing problems, unless iv just went into over drive last night and confused myself :(

i dont care bout conversion rates at the moment, just want to practice and get my hands dirty.

So yea, if anyone can help with a good method,or gimmie a few to check out n see for myself which suits my situation best.  ild be grateful,


Sorry for not putting in more time but like i said im pooped,
Thanks

Peace
Goonies never die!

lugh

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Re: Lpac ----> Ephedrine
« Reply #1 on: April 15, 2012, 12:06:16 AM »
« Last Edit: April 15, 2012, 02:19:58 AM by lugh »
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POSEIDON

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Re: Lpac ----> Ephedrine
« Reply #2 on: April 15, 2012, 04:41:44 AM »
Look this pdfs
The chemists are a strange class of mortals, impelled by an almost insane impulse to seek their pleasures amid smoke and vapour, soot and flame, poisons and poverty; yet among all these evils I seem to live so sweetly that may I die if I were to change places with the Persian king.
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kingnothing

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Re: Lpac ----> Ephedrine
« Reply #3 on: April 16, 2012, 01:24:18 AM »
Thanks boys and girls,

More then enough to keep me occupied reading n learning till i got understand it. 

Thanks again,
Peace
Goonies never die!

kingnothing

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Re: Lpac ----> Ephedrine
« Reply #4 on: April 16, 2012, 03:47:28 AM »
I looked though scimad for 6 hr b4 i came here  >:(

for whatever reason i couldn't find the diff methods for specific reactions.
I know it can be reduced but i want to see which synth would be best for my situation.

Eaither way, i was expecting the UTTFSE,
 im sorry but thanks alot, lugh

Worst case, for the next me that comes along its all there :)

peace
Goonies never die!

kingnothing

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Re: Lpac ----> Ephedrine
« Reply #5 on: April 16, 2012, 03:52:03 AM »
I should be right for now, i just Needed a starting point for my research

Thanks again.

Peace
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no1uno

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Re: Lpac ----> Ephedrine
« Reply #6 on: April 16, 2012, 09:38:02 AM »
Please stop with the post-whoring in this part of the forum. If you really must build up your posts, this is not the section to be doing that in.

With regard to SM, please don't bother using their search engine - it is worse than useless because there are far too many worthless posts clogging fuck out of it. Instead use the "site:http:www.sciencemadness.org ..." in google - put whatever you want to search for after that (Please don't tell me you cannot find l-pac related material on SM using that tip - there is one MAJOR contributor to the l-pac discussions on SM that is also on this board). If you actually do the work, I'd almost expect them to help you out.
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fishinabottle

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Re: Lpac ----> Ephedrine
« Reply #7 on: April 16, 2012, 10:00:26 AM »
The raw etherreal extract* of the biosynth (containing mostly l-PAC if done right) is reacted with methylamine and reduced with Al/Hg in the well known manner.

Look for patents written by Hildebrand and Klavehn.

* DCM would be fine too but the DCM would have to been removed. The extract has to stay cold as it tends top racemise (and selfcondense). If you cannot get ether look for diisopropylether which has similar propertiies but is AFAIK and here not watched.

The ultimative biosynth with sodium pyruvate and almost quantitative yields is to be found at SCM (look for author "Organikum" and text "holy grail").

After having aquired this information you can - so you want and need to - ask me by PM.

/ORG

kingnothing

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Re: Lpac ----> Ephedrine
« Reply #8 on: April 16, 2012, 09:59:19 PM »
Thanks mate, its not that i dident find any info on it, its just i found too much info on it ;/ if you know what i mean,

Thanks for the tip tho and offer, time to do some studying.

Peace,
And post whoring was the furthest thing on my mind, was just saying thank you for the links.
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zgoat65

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Re: Lpac ----> Ephedrine
« Reply #9 on: May 05, 2012, 06:29:45 PM »
Hope this helps.

EDIT: THE PDF FAILED UPLOAD.
« Last Edit: May 06, 2012, 12:09:01 AM by Wizard X »
If you build a man a fire, he'll be warm for a day.
If you set a man on fire, he'll be warm for the rest of his life

R.Esposito

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Re: Lpac ----> Ephedrine
« Reply #10 on: June 04, 2012, 06:28:15 AM »
Hi.

I want to ask from what Ephedrines are commonly used in pharmacy.
Otherwise, the more I want to make sure whether the PAC-L -> (-)-Ephedrine -> (+)-PSEUDO -> d-Meth? synthesis

java

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Re: Lpac ----> Ephedrine
« Reply #11 on: June 04, 2012, 01:51:18 PM »
......as explained to you at sciencemadness.....(-)-ephedrine will rotate to give you d- meth after you've done the removal of the OH group through whatever mnethod you choose be it HI made fro Iodine and HYpophosphorous acid....read more,.....java
¡Prefiero morir de pie que vivir siempre arrodillado!.Emiliano ZapataIt is better to die on your feet than to live on your knees!.......

bubble

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Re: Lpac ----> Ephedrine
« Reply #12 on: July 08, 2012, 01:08:19 PM »
 In my opinion you used not enough catalyst to hydrogenate the whole L-PAC. And in your 2nd Hydrogenation you upscaled the catalyst but also you've doubled the amount of L-PAC so it is in my opinion clear that the yield not as good as it could.

Because in your patent they use 15 parts of platinised Raney Nickel to 10 parts of L-PAC and i think you mixed it up, so you have not enough catalyst to hydrogenate the whole L-PAC to ephedrine.

R.Esposito

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Re: Lpac ----> Ephedrine
« Reply #13 on: November 20, 2012, 07:30:31 AM »
The project is now almost complete. I modified the yield ratio of catalyst Raney Nickel & Pd / C. However, the outcome is much weaker. I'll have to try to increase the ratio of L-PAC / methylamine. At what rate could be the perfect balance?

java

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Re: Lpac ----> Ephedrine
« Reply #14 on: November 20, 2012, 03:27:10 PM »
......its arguable as to the perfect ratio , most would say mole/mole...but her is a thread for you to read...java

http://www.sciencemadness.org/talk/viewthread.php?tid=7196
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R.Esposito

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Re: Lpac ----> Ephedrine
« Reply #15 on: November 28, 2012, 01:11:43 PM »
to java: tnhx for link... but I work with industrial bottle, that gives us pure methylamine in liquid base. Trying to apply it in ethanol to see how much it is possible to feed the ethanol to obtain a solution in a liquid base, which can then take an example, in milliliters. Methylamine far as I apply by pressure.