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Author Topic: propionoxy ester of loperamide being made as we speak and tried  (Read 1682 times)

no1uno

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #20 on: November 03, 2009, 05:20:50 AM »
It's in the reference request thread, posted by Java (as usual), the m-hydroxyPCP analogue IIRC

As to the fentanyl analogue - 4-methylfentanyl, also 4-carboxymethyl fentanyl (AKA Carfentanil)...
"...     "A little learning is a dang'rous thing;
    Drink deep, or taste not the Pierian spring:
    There shallow draughts intoxicate the brain,
    And drinking largely sobers us again.
..."

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #21 on: November 04, 2009, 04:40:09 AM »
looks to be a tall order doesn't seem feasable starting from the piperidinol or it's ester all of those start with a grignard on the piperidone and build from there not doable in any sense.

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #22 on: November 09, 2009, 06:25:01 AM »
update:!!!
iv, its heaven
 and it works sublingual too.
guys get to craking and stop complaing about w/d's just do it!

i just had surgery not a pain my body and my body feels very light and good too.
i feel wonderful
20 mg btw.
it's def more potent than heroin iv'ed and it does'nt make you pass out.
« Last Edit: November 09, 2009, 06:26:59 AM by jon »

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #23 on: November 09, 2009, 06:12:38 PM »
ya'll need to try this for real swij is'nt b.s.ing neither is ergoamide.
right now i feel completely serene what are you fellas waiting for?
christmas?
« Last Edit: November 09, 2009, 08:18:24 PM by jon »

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #24 on: December 05, 2009, 09:14:40 PM »
ergoamide was right bypasiing first pass metabolism is the only way this stuff works and boy is it a nice feeling too.
the trick is if your gong to toot it like i do, is to cut it with something that aids absorbstion like msm it also increases surface area of drug and makes it more effective.
anything inert that increases surface area will work you don't want to swallow the drip.
« Last Edit: December 06, 2009, 01:15:28 AM by jon »

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #25 on: December 07, 2009, 03:24:06 AM »
made the acetoxy ester today insufllated cut with mannitol to give more surface area and better absorption in the mucosa.
it's pretty nice too.
it could be explained like this the acetoxy is good the propionoxy when administered right is pure heaven.

Naphyrone

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #26 on: December 07, 2009, 12:10:43 PM »
This is great jon, I had been trying to figure out something to do with loperamide for months now and you answered it. On that note, I can obtain everything but the propionic anhydride. Also, what molarity is your H2SO4 ??? Could you post pics of reaction and result?

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #27 on: December 09, 2009, 07:23:38 PM »
really dont need to use h2so4 to catalyze the esterification zeiring sugests 1 drop for every 10 cc if you read you will find an easy synth for propionic anhydride in "other chemistry"
on a related note people have been trying to figure out for eons how to strip the chlorine atom ff that benzene ring and a personal comunication revealed that zinc and acetic acid could possibly be used to strip br off a highly deactivated ring in this case the ring is'nt very deactivated but it may work to some extent.
have a gander:


http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-3-23

"Tribromide 6 could be reduced somewhat selectively with zinc powder in acetic acid to give a mixture of de-brominated species 8–10"

nah can't be that easy

Sedit

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #28 on: December 11, 2009, 03:50:32 AM »
I have a question for you. Why can the acid form the ester here with H2SO4/carboxylic acid? Why the need for the anhydride here like me and Naf where talking about in the Unbinding thread? Its not a Phenolic OH.

Also has anyone tryed this with a P-glycoprotein inhibiter? Quinidine has been proven to give this opiate effects by preventing its destruction in the brain.
« Last Edit: December 11, 2009, 03:58:24 AM by Sedit »
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #29 on: December 15, 2009, 01:58:03 AM »
man i tried p-gloycoprotein inhibitoers but i just snorted about 15 mg and i feel so relaxed i'm melting into the chair this is a good narcotic!!!

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #30 on: December 15, 2009, 02:00:16 AM »
I have a question for you. Why can the acid form the ester here with H2SO4/carboxylic acid? Why the need for the anhydride here like me and Naf where talking about in the Unbinding thread? Its not a Phenolic OH.


in reply to: anhydrides are easier to work with you'll just love it they evap clean no bumping i mean i love prop anhydrde!!!
pm me i''l teach you just how
« Last Edit: December 15, 2009, 02:12:55 AM by jon »

Sedit

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #31 on: December 15, 2009, 04:02:38 AM »
Ill hit you up later I have a few things to speak about... I do not believe that the anhydride is needed and that Glacial acidic acid can be used :o
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #32 on: December 15, 2009, 04:08:08 AM »
it will go to 63 equilibrium at t+20hrs that's it anhydrides in excess near qauntitative conversion why don;t just do it like the big boys do it????

Sedit

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #33 on: December 15, 2009, 04:12:48 AM »
Because Im lazy and cheep now be quite ;D
There once were some bees and you took all there stuff!
You pissed off the wasp now enough is enough!!!

jon

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #34 on: December 15, 2009, 06:37:42 AM »
i done it with gaa it works but not with proionic acid it does'nt work they are a little different in reactivity.

ahhhhh!!! i can feel this music
sorry it's an mdma thing.

http://www.youtube.com/watch?v=ZEaRJhMjruA&feature=related

feel the love!!!
http://www.youtube.com/watch?v=MMyfmfH8Cto&feature=related
« Last Edit: December 15, 2009, 06:53:59 AM by jon »

chemrox

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #35 on: April 02, 2010, 07:36:27 PM »
@no1uno:  "there are PCP analogues (ie. very fucking similar if a cyclohexyl group were added in), modified on the benzene ring, that reportedly have high affinity (some 430 times higher than PCP) for the morphine receptors."

Could you expand on this last-possibly with w ref or two?
Thanks,
crx

student

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #36 on: November 08, 2010, 09:25:02 AM »
Can someone tell me if I have correctly drawn the structure:

Enkidu

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #37 on: November 08, 2010, 09:47:52 AM »
It's correct except that there is no double bond near the ester and the amide needs two methyl groups.

student

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #38 on: November 08, 2010, 10:30:50 AM »
Thanks, is this looking better?
 

Enkidu

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Re: propionoxy ester of loperamide being made as we speak and tried
« Reply #39 on: November 08, 2010, 07:47:35 PM »
Yep.
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