200 mg's no numerical error! I was terrified when I learned he had done this and rushed to monitor him... I think the receptors get saturated and anything over that point only prolongs the duration.  I have been amazed time and time again with the bodies tolerance to alot of pyschotropics (now don't go experimenting...).

Is the ester analogous to any schedule 1's or 2's?

Yeah, loperamide is obviously not scheduled, I was asking if the ester is close to any other scheduled opiates in structure. Example: methoxetamine is an analog of ketamine (shedule 3, so not covered by analog act), however methoxetamine may be close enough to PCP to be covered.

AA does not apply to schedule III's, but I'm not argueing that it isn't covered.

Thanks Jon!

okay this is an interesting paper this explains the SAR's of phenylanilidopiperidines
the SAR's of these compounds and of the meperidine class are pretty much analogous.
it shows here the potency of p-chloro fentanyl to be 1/30th of that of fentanyl
or about 1.5-3 times the potency of morphine.
and i found this to be intriguing because it just so happens that propionyl loperamide is exactly in that range of potency pretty close to heroin.
from this is can be inferred that dechlorination of loperamide would yeild a product 30 times stronger upon esterification.
or strikingly close to that of fentanyl.
talk about "reverse engineering"

i initially thought that lithiation of loperamide was not feasible because of the dimethylamido moiety.
having a propensity to enolize and from there the organic base could induce anionic polymerizations of the enol.
but seeing how the carbon alpha to the dimethylamide is qauternary ie. bearing no hydrogen, this is simply not possible.
so the forseeable product would be the phenyl lithium oxo lithium salt.
which upon quenching with 2-propanol would yield the dechlorinated product. as the oxo lithium salt.
or it could just be quenched with dilute acid.
this appears to be the most straight forward approach because of lithium's reactivity towards aryl chlorides.
the paper is attached.

they go to liar school for 8 years they know how to distort facts and sell it to a bunch of knuckleheads another part of the process they control in part is jury selection they study the psycology of certain demographics in order to handpick thier juries unless you got a paid juror, or a paid judge (which is indeed possible) the odds are against you in any (St. vs. joe blow) case.
For the peace and dignity of the state, I rest my case.

they go to liar school for 8 years they know how to distort facts and sell it to a bunch of knuckleheads another part of the process they control in part is jury selection they study the psycology of certain demographics in order to handpick thier juries unless you got a paid juror, or a paid judge (which is indeed possible) the odds are against you in any (St. vs. joe blow) case.
For the peace and dignity of the state, I rest my case.

Ha, I rmember living in this house. I was studying a biomed sc degree with an unofficial chem major. Just utilized the electives, which were the same for chem major. Well anyway, I met this person, and everything I said he argued. everything. I mentioned drug addiction. it came up in a conversation, and he mentioned that food and water is also addictive. YES YES, but I am specifically talking about Drug addiction, not the concept of addiction itself. I mean everything Jon, every fucking comment I made, he twisted it, to present an agenda that he knew best. I eventually asked him what he was doing, as I found out he was studying. The lying sack of shit said. I got a little something going on, not important. OH okay, I said to myself. Be like that. I later found out he was studying law. 1st year and must of thought that if he said it, then Id think something or something like that. I dont give a rats ass if he was studying rocket science, or theoretical physics, what I dont like is ASSHOLES who aren't fucking honest. He bombed out, but he would of made a good legal person. He twisted so well, he avoided telling the truth, and imo, he would of excelled. Cunt of a man. Lying manipulating bitch. Sort of guy who always had a best friend who was always percieved as DUMBER than he. Must of made him feel fucking smart. I feel like popping the cunt everytime I think of him. Not him, just the him he thinks he is.
Sorry end of rant.

and they are hypocrites too i supplied a law student with fuck tons of cocaine and he turned out to be a DA that went to the restroom every 5-10 minutes

well he probably did'nt have a very pure sample.
i noticed he deviated from my advice when asked what to do, so i don't find that very suprizing.

i found citrate salts of amines are hard to crystallize because of all the potential sites for hydrogen bonding you need a solvent and then something very non-polar to crash it out of solution advise your chemist.