Can propionyl chloride be substituted f/ propionic anhydride

MobiusDick · Sat Sep 03, 2005 12:51 pm

Can propionyl chloride be substituted for propionyl anhydride in the following carafentanil patents?
Here are the references:

https://www.synthetikal.com/Rhodiums_pdfs/chemistry/carfentanil.html

MobiusDick

Lego · Sun Sep 04, 2005 3:19 am

Yes, should work without any problems. You can also synthesise propionic anhydride from propionyl chloride and propionic acid.

Fentasies · Thu Sep 08, 2005 12:20 am

Mobius im going save you some trouble my friend, dont worry about Carfentanil. Its duration of effect barely lasts 15 minutes in man. Euphoria is there, but not worth it considering the miniscule duration. Its very rapid onset like most fentanyls. Pretty deep respiratory depression, but this is rather common to most/all fentanyl's.

Not worth it because of the duration. Dont care how much profit you could turn, it would never sell no one wants to fix 4x an hour, the only person whod buy it is Osama. Besides, there is even MORE powerful fentanyls that have longer durations and seem overall better candidates than Carfentanil, beleive it or not.

Plus there is thousands of other candidates aside from just fentanyl's, the benzimidazoles such as Etonitazene and Clonitazene and their possible analogs/derivatives/isomers seem like another interesting class of drugs for smack market replacement needs.

BTW, does everyone know the north-east US is in the middle of an emerging fentanyl crisis?? Even on NBC they had a warning saying east coast heroin buyers to be careful, some new 'additive' in the heroin, but we all know they really mean its fentanyl.

Heres more for those who luv this shit;

Gang Allegedly Hands Out Free, Phony Heroin
Multiple Victims Fall Ill After Using Drug Sample

POSTED: 4:21 pm CDT August 17, 2005

CHICAGO -- A synthetic drug disguised as heroin which caused multiple overdoses on the West Side this week had been given away by gang members in order to acquire new customers, police officials said Wednesday.

The drug, Fentanyl, was distributed for free by the New Breed street gang at the Chicago Housing Authority ABLA Homes development, Police Superintendent Philip J. Cline said at an unrelated news conference.

The fake heroin was packaged in small orange bags, Cline said.

The ABLA Homes building at 1254 S. Loomis St. has been a stronghold of other gangs and the New Breed was attempting to get new customers, Cline said.

No one was in custody as of 2:15 p.m. Wednesday in connection with the drug give away, Police News Affairs Sgt. Robert Cargie said.

Three of the victims were found around 9:30 a.m. Tuesday at 1520 W. 13th St., police News Affairs Deputy Director Pat Camden said. They were unconscious and had labored breathing, he said.

None of the overdoses or reactions was considered to be life-threatening and all victims were treated and released from local hospitals, he said.

Two of the victims were able to later tell police that a 16- to 17-year-old boy had been handing out free heroin in orange baggies at 1440 W. Hastings St., Camden said.

Since Tuesday morning, four others had been found in the area around the 13th Street address ill from the free drugs, Camden said

All heroin accepted by the victims had been consumed, Camden said.

Police were still investigating the scene and talking to witnesses, Cargis said.

And so it begins, the second wave of fentanyl and their analogs manufacture in north america since george marquardht followed by michael hoovey. I have predicted this for sometime. You better get in the game while its hot folks, cause pretty soon fentanyls gonna be the next drug to be 'demonized' by the media and rediculously 'controlled' by the government.

MobiusDick · Wed Sep 21, 2005 2:41 am

The beta hydroxy group tends to increase duration of action in propioanilides as in beta hydroxy alpha methyl fentanyl. Often hydroxyl groups increase the ease of hepatic glucoronidation, but with propioanilides this does not appear to be the case. The beta hydroxy analogue of carafentanil would probably last longer.

ergoamide · Wed Sep 21, 2005 4:43 pm

In the same way propanoic chloride can be substtuted can acetyl chloride be substituted in heroin synth.

Fentasies · Thu Sep 22, 2005 12:47 am

How do you know Beta Hydroxy Alpha Methylfentanyl really lasts longer? Because Drone said so?? He was merely speculating from looking at fentanyl SAR data, but SAR data doesnt always prove true, and we all know fentanyl is a vary diverse compound and the SAR data regarding it has been shown to be inaccurate in multiple cases of attempts to gauge potency of a new fentanyl analog based solely on that data.

The fact that Drone never gave an actual duration of effect or even dosage for his supposed analog makes me question wether he ever actually made it and if he did-did he ever actually TEST it or just showboat about it. Usually if your gonna post about something youve supposedly mastered, you wouldnt leave out such amateur details regarding its basic profile.

Not saying that Beta-Hydroxy addition wouldnt increase carfy duration and potency, but even if it increases it, Carfy is already so short how big a difference do you beleive there can be? Even if it doubled its duration, which I doubt it would, it would only land it about 30-60minutes TOPS in duration. Not too great, when for the same amount of work you could acheive far better analogs.

But of course, if its simply for the sake of science, truck on. But if it has some financial meaning, id be alot more careful where you put all your eggs.

Stinging_Nettle · Thu Sep 22, 2005 9:36 pm

Im not sure why nobody ever brings up the subject of levophanol. My guess is that at a dosage of a few milligrams lasting the duration of an entire day, even the product distributed as the racemic compound has got to be considered an interesting alternative and is a wonder why this has not taken to the clandestine setting. Details for its synthesis can be found on rhodium or in various of the e-books published by Daniel Ledinicer on the Wetdreams website.

Fentasies · Sat Sep 24, 2005 1:10 am

^

Yes levo is okay, but its dose is too high. MG's? pfff who ever doses in the MG's anymore!

Lofentanyl lasts pretty much all day, and is alot less than a MG for a dosage...

Stinging_Nettle · Sat Sep 24, 2005 1:27 am

you would have a hell of a time trying to make that one! I mean most of the dukes in this place arent exactly kicking it around with the big pharma companies.

stooge · Sun Sep 25, 2005 2:20 am

swis would think it would be worth the time to bother oneself to find out how to synth it, but the precursors are like, from mars, or so ... no clue how one could ever get them Sad

nobodyimportant · Sun Sep 25, 2005 3:15 am

Believe SWIM, fent the vanilla kind is easy to make and oh so lovely. I just wish the main precursor does not become a watched substance as that would be a real pain in the ass.

I wish people just stick to plain heroin and leave fent and its analogs to the select few. Also, anyone making it, please be smart about distributing it. There are people who earn a living selling this. Not much, but about $5,000 per month more or less. So, stop selling to street idiots and selling it stupidly. DO NOT CUT with fucking lactose cause I guarantee you will end up with hotspots. There are other ways.

Also, a question: Can Propionyl Chloride be substituted with something else, like propionic acid etc? Please, I just need to know. You know how curious I am.

Also, I DO NOT IN ANYWAY CONDONE any thing illegal for sale, nor am involved in making anything even slightly questionable. All of my rantings are just rants and I live in a fantasy world.

Stinging_Nettle · Sun Sep 25, 2005 1:00 pm

If one had propanoic acid then they could use this to make propanyl chloride with SOCl2 for example.

stooge · Sun Sep 25, 2005 2:16 pm

as this is/has become a thread on fenta, swis wants to ask a question that keeps him wondering for years now without success:

When looking at Siegfried's Synth - What Fenta Analog is it excactly? As it's said to have a duration only a little shorter than normal Brown it can't be just the plain stuff, right?

Thanks!

nobodyimportant · Mon Sep 26, 2005 4:10 am

It is the plain vanilla kind. What I mean is the one that was first synthesized by a Belgiun in the 60s. Fent HCl. Seigfried's general idea is spot on, but has many flaws if one were to try and proceed step by step. Once you get what he is going after and understand the whys instead of just the hows, you are good to go. But then again, making the stuff isn't for your standard ---- cook who just follows step by step instruction manuals. One needs to respect the stuff and use their own brains to actually make it.

However, you are better off making other compounds. Trust me, fent has little recreational value and I have to warn everyone from using it. It is insanely addictive and the withdrawals are just terrible.

Fentasies · Tue Sep 27, 2005 2:37 am

Siegfried was obviously getting ahead of himself. His generalization that fentanyl is only a bit shorter than heroin is rather off and sounds like he wanted to make it sound more appealing..... in SWIMs experience with fentanyl in an actual medical setting was about an hour and a half to two hours tops. Heroin more in the 4-5. Id consider that a fairly large difference.

Now does anyone know the duration of 3-methylfentanyl?? Id suspect thats closer to H in duration.