Can you steam still it. If not just go and  base to a ph of 10 (na2co3)  and acidify to 7 check the ph of the base first but swIM thinks its not as high as MA. Just a guess but Sure it would work.

What do you do if you have 3g of codeine base and I/RP, ratios? And when reduced use the post-reaction method as with meth ? Not making shit krokodil injectable liquid, I want for smoking on foil.

regards

Reduced? Your not trying to reduce anything your trying to cleave an Ether. This can only end badly.

Pyridine HCl works, you can find this and more information on rhodium. UTSE.

Desomorphine via HI generated in situ from P and I2 is a flat out bad idea. The crude is a complex mixture that is difficult to resolve, the yield of the desired product is low, and there's no easy way to clean it up - acid/base extractions are out, as desomorphine is amphoteric (and so are many of the side products), and any recrystallization carries the risk of co-crystallization of impurities and loss of a substantial amount of material. The only good way to clean up a mess like what this reaction provides is to run a column, and not many clandestine chemists have such resources, or even the experience necessary to do such a thing.

Try a Birch on codeine. Li/NH3 reduces allyl alcohols quite cleanly and selectively, so it'd probably give you desocodeine, which, given studies on structural activity relationships in opiates, should be fairly potent (not so much as desomorphine, but improved yields should make up for it) and have high oral bioavailability. This isn't amphoteric, so it could be cleaned up with an acid/base extraction. The possibility of ingesting extremely toxic phosphorus compounds would be avoided entirely.

Esters of 14-hydroxycodeinone would fit the bill there. 14-Cinnamoylcodeinone is approximately 180x morphine, and can be prepared in three straightforward steps from codeine: first, MnO2 (prepared in a specific manner) or another reagent capable of converting codeine into codeinone is used to effect said transformation, then catalytic aqueous CuSO4 or MnSO4 is employed to oxidize codeinone to 14-hydroxycodeinone using atmospheric oxygen, and finally this is hit with cinnamoyl chloride or bromide to generate the ester.

There are many other possibilities that begin with codeine, but this is probably the easiest. Search for posts by "Assyl Fartrate" and throw in terms like "morphine," "oxycodone," "oxymorphone," "codeine," "fentanyl," and "analog" and you may find some summaries of ideas formerly posted. Also search for posts by "jon" as he is our resident medicinal chemist and his knowledge in this area is considerable - he has contributed greatly to the pursuit of the goal of easy opioid synthesis in a home environment.

If you are actually serious about pursuing one of these syntheses, Assyl will walk you through the process, given that you have accepted a gentlemen's agreement that you will stick around to share your experiences with the end product.