Author Topic: LSD from HBWR  (Read 1352 times)

director of sound

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Re: LSD from HBWR
« Reply #80 on: October 27, 2010, 09:59:06 PM »
acuall fresh hawaiian seeds, i have a friend on maui that can aquire them for me every now and then. when working with something like lysergamides from seeds (other than ergot) a larger scale is much more feasable when you think of it. first if you were to extract say 50g of seeds you would only get about 200mg of mixed lysergamides that on hydrolysis to lysergic acid would only give about 60mg mabey a little more if you were to make the hydrazide (150mg +/- 25). so you wouldnt be able to do very much with 150mg or less so if you can get your hands on half a kg or better you might be able to make something from it. the avrage hawaiian baby wood rose seed weighs 125mg so there are 8 seeds per a gram, go to a site like that shamanjungle bullshit place where they sell by seed count, 500 seeds would be a little over 60g for about $16 (not hawaiian seeds though) its gonna cost you $125+ to get 500g of seeds that might give you 1.5-2g of lysergamides to play with. my suggestion is that if you are gonna go as far as to mabey attempt this, it dosent cost that much to go to hawaii in September. make some friends, find a big old hbwr vine and ship seeds back in coffee bags. just make sure they are the foil lined ones and vacuum seal them before you ship. a few weeks squating on the pipeline for free will let you scroung up several KG pretty much for free (well you plane ticket S&H at least). so now when you fly home you will have 10, 20 whatever kg you gathered in your time there waiting for you. now you have something to work with, if you were to go the hydrazide and POCl3 route 10kg might get you 10-15g....... now would that be worth a $500 plane ticket?
« Last Edit: October 27, 2010, 10:02:00 PM by director of sound »

akcom

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Re: LSD from HBWR
« Reply #81 on: October 28, 2010, 12:27:30 AM »
What else is lysergic acid sensitive to besides light and bases?  I seem to remember reading something about sensitivity to water.  Any references would be much appreciated.  why not hydrolyze bromocryptine, form & decompose the gringard and viola.  Lysergic acid.  Seems a lot less messy.

Trips

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Re: LSD from HBWR
« Reply #82 on: October 28, 2010, 12:32:47 AM »
I certainly have no interest in actually carrying out this procedure! And even if I were, it would certainly not be to sell! I couldn't survive prison.  Though just for a thought experiment I'd like to potentially get like 100 mg.  If you started with 100 grams of seeds, you don't think you could theoretically wind up with a 100mg LSD, all said and done?  Even 50 mg of nice pure fluff is 500 hits!  Even that seems so very excessive for personal use.

Trips

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Re: LSD from HBWR
« Reply #83 on: October 28, 2010, 12:34:42 AM »
Sending prescription drugs across the border is sketchy, for one.  For two, its expensive.  And for three, there's something satisfying about working directly with a life form, synergistically, to create something better than either of you alone can do :P  (Well, total synthesis is NOW possible, but...meh)

solidstone

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Re: LSD from HBWR
« Reply #84 on: October 28, 2010, 10:47:26 AM »
Well I just aquired 2 lb's of Mg shavings, so I'm curious about the Grignard with Bromocryptine.  Are there any confirmed procedures for this or is it merely a popular pipe dream?

Getting prescription drugs over the border is not very difficult, especially if its packaged as America's favorite anti-impotence drug, perhaps slide a natural male enhancement pamphlet in with the goods make the custom agents nice and uncomfortable so they'll stamp her right through ;)

akcom

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Re: LSD from HBWR
« Reply #85 on: October 28, 2010, 12:54:21 PM »
Trips, like solid said getting drugs over the border is extremely easy (and cheap).  Especially compared to a trip to Hawaii (not knocking DOS's method).

Solidstone, no literature, but it's an exceedingly easy reaction to perform.  Dimethoxymethane could probably be used instead of ethers.  I would probably use Et2O just to be safe
« Last Edit: October 28, 2010, 11:05:25 PM by akcom »

Trips

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Re: LSD from HBWR
« Reply #86 on: November 01, 2010, 04:39:08 PM »
Nobody has anything to comment on the feasibility of a synth. starting with 50-100 grams of HBWR?

jon

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Re: LSD from HBWR
« Reply #87 on: November 01, 2010, 06:13:25 PM »
grignard rxn on bromocrytine nice dream.
just buy the ergotamine

director of sound

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Re: LSD from HBWR
« Reply #88 on: November 01, 2010, 06:58:22 PM »
50-100g wouldnt make alot and you'd have to do it on a micro scale with 25-50ml glassware because after you convert the LSA to lysergic acid you wouldnt have too much to work with. youd get maby 350-400mg LSA from 100g HBWR and depending on how you convert that it could end up being 100-250mg lysergic acid.... it could be done though. just get all your ducks in a row first before attempting anything otherwise you'll loose product by the hour once its extracted.

director of sound

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Re: LSD from HBWR
« Reply #89 on: November 01, 2010, 07:00:31 PM »
as for bromocriptine, if you think you can pull off a grignard, go right ahead as i found 2.5mg pills in a 30ct for $24 online. ill have to find the link again though but it looked like it was OTC and nothing said an rx was needed to buy it.

tregar

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Re: LSD from HBWR
« Reply #90 on: November 01, 2010, 07:22:36 PM »
Really have enjoyed reading this beautiful thread over and over, excellent info director of sound, keep up the good dream work.
« Last Edit: November 01, 2010, 07:24:08 PM by tregar »

jon

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Re: LSD from HBWR
« Reply #91 on: November 01, 2010, 08:38:36 PM »
bromocryptine and grignard schemes pipe dreams why?
the amide link bears a proton and a whole lot of other shit i haven't accounted for that i don't know about that complex side chain.
now you can possibly reduce it with acetic acid and zinc.

solidstone

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Re: LSD from HBWR
« Reply #92 on: November 01, 2010, 08:54:44 PM »
Pipe dream simply because there is no experimental data available on the topic.  I will however have the magnessium chips in the next few days, and am contemplating ordering some bromocriptine for a microscale experiment.

If anyone wanted to run this experiment parallel to my attempts I would be more then willing to share my magnessium for the cause.

jon

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Re: LSD from HBWR
« Reply #93 on: November 01, 2010, 09:24:32 PM »
pipe dream because of the basic principles of organic chemistry.

solidstone

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Re: LSD from HBWR
« Reply #94 on: November 01, 2010, 09:46:11 PM »
You think its not a feasible reaction route?  Do explain and save me a headache.

akcom

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Re: LSD from HBWR
« Reply #95 on: November 01, 2010, 11:15:03 PM »
What I believe jon is saying is that a grignard reagent will preferentially cleave a proton from the amide.  I don't know shit about intermolecular grignards, or amide chemistry for that matter, so I have no idea what the resulting product would look like.  The dimer is probably more likely than the intermolecular grignard.  Props to jon for knowing his shit (as always lol)

jon

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Re: LSD from HBWR
« Reply #96 on: November 01, 2010, 11:15:38 PM »
well if you went all the way to 2-bromodelysid it would work but with that complex side chain and the fact that the amide is secondary it will not work.
there is another method proposed on SM that just might work by just heating in zinc and acetic acid at around 80 or so it works for debrominating thiophenes at the carbon alpha to the heterocylcic residue the sulfur in that case but in this case it is very similar you have a brominated carbon alpha to the nitrogen heterocylclic residue it should work the same exept sulfur chemistry is a bit quarky but i see no reason it won't work.
except ergolines have that touchy conjugated double bond that lewis acids like zinc acetate might influence and cause unwanted side reactions.
like dimerization for example because ergoline chemistry is a royal pain in the arse.
but if you got bromocryptine on hand give it a whirl.
it will only cost you a few quid to find out.