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Author Topic: loperamide is it possible to form a grignard complex of???  (Read 654 times)

Naf1

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Re: loperamide is it possible to form a grignard complex of???
« Reply #60 on: March 10, 2010, 03:34:06 AM »
Seems he flew the coup, I think he would have liked this one so here you go. Magnesium, isopropyl alcohol and HCl, hmm I really think he would have liked this, anyway.....

REDUCTION OF ORGANIC HALIDES. CHLOROBENZENE TO BENZENE
Organic Syntheses, Coll. Vol. 5, p.998 (1973); Vol. 47, p.103 (1967).

http://www.orgsyn.org/orgsyn/default.asp?dbname=orgsyn&dataaction=search&metadata_directive=blind_gui&formgroup=quick_form_group&Preps.CollVol=5&Preps.CollPage=998&order_by=Preps.CollPage%20ASC

jon

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Re: loperamide is it possible to form a grignard complex of???
« Reply #61 on: July 07, 2011, 04:10:28 AM »
on that note after all the research i did i found the best way to dehalogenate that bugger is with pd/c in methanol using ammonium formate as hydrogen donor.
it's chemoselective it takes 30 minutes and the yeild is 100% conditions are room temperature and stirring.
workup is as easy as filter, evaporate, then acid base workup.
references coming soon.

akcom

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Re: loperamide is it possible to form a grignard complex of???
« Reply #62 on: July 07, 2011, 06:49:45 AM »
Jon, how are you reactivating your Pd/C?  Simple base wash?

jon

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Re: loperamide is it possible to form a grignard complex of???
« Reply #63 on: July 08, 2011, 08:01:47 AM »
that's the standard way, the chemical engineers at the catlytic reformation plants use ammonia to wash thier pd/c for reuse.
probably to get rid of sulfide contamination.
i don't have the paper on pd/c reconstitution anyone care to share it?
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