Also - this is not just chemistry questions, it is any sort of questions - except for ones related to this sites operation, Me, mods, etc... post those in the Site section of this site or just PM me - whatever you prefer.

here i will try again hehehe

at bright star paper, when we makes methylamine hcl, he add 350ml of water with the paraformaldehide and amonium!
at the other paper at rhodium with picture steps, NO water is mentioned!

is water nedded for reaction? or no?

thanks

Dumb question thread would probely fell like home hehehe 

meant like my home hehehe just playing because i think i make dumb questions sometimes....dumb like obious questions for you guys hehehe but mostly its because the lack of experience with materials, set ups, chem knowladge (since i took my first chem lessons at a foreign school) hehehe but im patience!

like asking if the formaldehide and amonium chloride needs water to form methylamine i didnt think was SOO dumb hehehe

peace

If you have "obvious" questions, but want to communicated about it.. try #chemistry over on freenode. They are a helpful lot.

So...

After successfully nitro/ketone reductive amalgamation to get MDMA I decided to distill most of the MeOH to reuse it next time (It is rich in methylamine!) but i unfortunately scorched a bit of MDMA or what not in that flask and I got very lousy yields from that reaction.
After that MeOH was staying a while in the closed bottle it turned yelowish-green.
This might be doe the slight contamination with Fe and Fe oxides.

But...
Is it possible that MDMA freebase came along the MeOH and methylamine forming aesotrope!?

Would the oxime of methyl cinnamic aldehyde [cas 101-39-3] reduce to methamphetamine in Antibody's acidic Al/Hg reduction?

I assume if this worked it would be common practice, so I must be missing something obvious, and I'm curious what.

To summarize: nitration of 1-naphthoic acid and reduction to amine, forms 3-amino-1-naphthoic acid. ( haarp://www.jbc.org/content/130/1/407.full.pdf ) A second nitration of this followed by reduction to the amine and dehydration to the lactam, yields 3-aminonaphthostyril. The skraup synthesis with glycerol yields a quinoline, and reduction with sodium in butanol yields ergoline - this is old stuff. The sodium metal reduction is rather inefficient, in the case of synthesis of dihydrolysergic acid around 8% (but perhaps there's a way to optimize it?)

Also note that 3-aminonaphthostyril, when reduced at ~20% yield with sodium to the b-amino 3,4-trimethyleneindole, probably is a drug in its own right - and would have little risk of the condensation that plagues tryptamines, under attempted Eschweiler Clarke alkylation. Although, "Substituted Naphthofurans as Hallucinogenic Phenethylamine-Ergoline Hybrid Molecules with Unexpected Muscarinic Antagonist Activity" might suggest a similar activity of this aminotrimethyleneindole, and an antimuscarinic psychedelic could be a very dangerous drug.

Instead of the skraup synthesis with glycerol, cyanomalonic dialdehyde - the subject of Uhle's paper cited below, etc. With catalytic hydrogenation of the quinolinium thing, then Na/BuOH, hydrolysis yields 9,10-dihydrolysergic acid, although in somewhat low yield.

Now I must wonder: with NaBH4 under the proper conditions, that same methyl quinolinium salt seems like it might be reduced to the dihydroquinoline. Does it simply not? (If not, there are specific syntheses for dihydroquinolines.) As sodium doesn't seem to reduce alkenes, reduction should yield racemic paspalic acid, which is known to be isomerized to lysergic acid. So what is it I'm missing? Sodium simply reduces it completely?

THE ERGOT ALKALOIDS. XX. THE SYNTHESIS OF DIHYDRO-dl-LYSERGIC ACID. A NEW SYNTHESIS OF 3-SUBSTITUTED QUINOLINES
FREDERICK C. UHLE, WALTER A. JACOBS
J. Org. Chem., 1945, 10 (1), pp 76–86
DOI: 10.1021/jo01177a014
Publication Date: January 1945

Dihydroquinolines. I. The Action of Metal Hydrides on Quaternary Quinolinium Salts
ROBERT C. ELDERFIELD, BRUCE H. WARK
J. Org. Chem., 1962, 27 (2), pp 543–548
DOI: 10.1021/jo01049a048
Publication Date: February 1962

Thanks RoidRage!

Hello,

simple/silly question:

is there anything else other than acetic anhydride or acetyl chloride which could esterify THC to THC-O-acetate?

Thank you

Hello all,
My question is in relation to "Reductive Amination of P2P through Catalytic Hydrogenation Using Adams Catalyst” on the Rhodium mirror. Specifically sub-section 4.4.2  "Iron Reduction of 1-phenyl-2-nitropropene to 1-phenyl-2-propanone."

"Pour 15 liters of clean tap water into the vessel. Follow this with 4000g of catalytic iron, 3400g (20mol) of 1-phenyl- 2-nitropropene and 40-50g of ferric chloride. Assemble the top with the condenser in the reflux mode, start the water running through the condenser, begin stirring, and fire up the propane burner. Watch the thermometer and turn off the heat when the temperature reaches 90°C. Slowly add muriatic acid in small doses over a 2-hour period."

My question is about the 40-50 g of ferric chloride.  I’m wondering if the ferric(III)chloride isn't just changed to ferrous(II)chloride as soon as the HCl is introduced.  I am thinking that the Ferric(III)chloride as a catalyst is even needed.  If I am incorrect can someone help me understand the need for it. 

Thanks,

F.G.