...for no1uno
@Alchemyst: Sorry, but no access for me to this journal. I doubt that you will find somebody with access, as "Future Medicine" is really not well known resp. reputated.
- Murphy
Schiff bases. Part I. Thermal decarboxylation of -amino-acids in the presence of ketones
A. F. Al-Sayyab and Alexander Lawson
J. Chem. Soc. C, 1968, 406 - 410,
Abstract
A number of Schiff bases derived from -amino-acids and hydroxy-substituted aromatic ketones have been prepared. Their infrared spectra suggest that their relative stability to hydrolysis as compared with those from ketones with no hydroxy-groups is due to hydrogen bonding. The thermal decomposition of -amino-acids in the presence of ketones, followed by hydrolysis, produces the amines corresponding to the amino-acids or the ketones (transamination) or both, depending on the nature of the amino-acid and the ketone used and also on the method of hydrolysis. In the case of amino-acids with a quaternary -carbon atom, transamination is the principal reaction. The preparation of tyramine, tryptamine, and histamine in good yield from the corresponding amino-acids is described.
Schiff bases. Part II. Some ketimines prepared by decarboxylation of -amino-acids in the presence of ketones and their reaction and that of aldimines with phenyl isocyanate
A. F. Al-Sayyab, A. Lawson and J. O. Stevens
J. Chem. Soc. C, 1968, 411 - 415,
Abstract
Some ketimines prepared by thermal decarboxylation of amino-acids in the presence of aromatic ketones, or directly from the corresponding amines, are described. In the case of -hydroxy-amines, ring closure takes place to give oxazolidines. Aromatic ketimines derived from o-hydroxyacetophenone react with phenyl isocyanate to give coumarin derivatives. Aldimines prepared from o-and p-hydroxy- and -methoxy-substituted benzaldehydes react with phenyl isocyanate to give s-triazine derivatives.