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News / Re: DMT found naturally occuring in the brain
« Last post by aniracetam on March 27, 2020, 02:26:31 PM »
he's saying without reading the details of the study,  people who accept the alternative hypothesis would parade around falsely-claiming "we told you so" (DMT is produced in the brain).

I've read articles on the matter for 21 years, studied biochemistry, and more importantly, metabolism. To date, there has been no evidence for INMT expression in the human brain cortex, much less the pineal gland; however, it was found that DMT may be stored in neural vesicles. Since it readily diffuses across the BBB, it's more plausible that production occurs in the peripheral tissues, where INMT is expressed, and camps out in said vesicles. For what purpose, who knows.

Using logic and common sense, it wouldn't seem likely DMT production occurs in the brain, since >90% of serotonin production occurs in the gut. DMT production occurs as a side-reaction, which is not genetically preferred, after AADC (aromatic- aminoacid decarboxlase) removes the CO2, a rate-determining step. DMT production inhibits serotonin production, and vice versa, via feedback inhibition. It would seem more likely that production would occur in the gut, and surrounding tissues/epithelial cells, where INMT is known to be expressed.
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News / Re: DMT found naturally occuring in the brain
« Last post by Grud on March 27, 2020, 02:01:10 PM »
https://www.aliusresearch.org/nichols-nichols-endogenous-dmt.html

I'm not sure if i understand the last paragraph can anyone please explain and give their opinions?
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Harm Reduction Resources / Re: DIY Medical Tools to fight the Pandemic
« Last post by maker on March 22, 2020, 09:11:10 PM »
Is this makeable to a home chemist? It seems to be the only, sorta proven, treatment for Corina virus.

https://en.m.wikipedia.org/wiki/Hydroxychloroquine

https://www.beilstein-journals.org/bjoc/articles/14/45
https://www.ncbi.nlm.nih.gov/pubmed/29623120

There is a thread on SM that is pretty recent concerning this. Check it out, there may be some goodies within.
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Harm Reduction Resources / Re: DIY Medical Tools to fight the Pandemic
« Last post by Dyinglight on March 22, 2020, 09:08:45 PM »
Yeah it's the person (s) that I'm caring for that I'm worried about I ain't scared just annoying that no ethanol is available otc now and some other dumb shot nearly got stranded in the lab other day as well panic is crazy here and I'm tired of it and just posted that attachment because I thought it was interesting I know stimulats have a tendency to make you feel well anyway kinda
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Harm Reduction Resources / Re: DIY Medical Tools to fight the Pandemic
« Last post by carl on March 22, 2020, 08:45:40 PM »
Well, I would assume most of us are relatively young and healthy individuals(stop consumption as long as the weather is still cold to assure good immune system functions), without preexisting conditions, then we should be well anyways.
It is not worse than the flu.
I hope I get it soon too as well as the majority of people, so that the hysteria is over fast.

99% of the people who died in italy were elderly with 2-3 preexisting conditions.
Also, in italy it is common for grams and gramps to live in a household with their younger offspring, which faciliates the chances to become infected greatly.

Just keep in mind that the majority of the people who got it are already healthy and well again and have overcome the infection.
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Harm Reduction Resources / Re: DIY Medical Tools to fight the Pandemic
« Last post by Dyinglight on March 22, 2020, 08:14:56 PM »
Well shit creak in my neck of woods now getting put on a 12week isolation any time soon

Seen this a while ago what do you guys reckon seen people in hospital and they don't look happy they can't breath...
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Harm Reduction Resources / Re: DIY Medical Tools to fight the Pandemic
« Last post by eesakiwi on March 22, 2020, 04:14:56 PM »
Is this makeable to a home chemist? It seems to be the only, sorta proven, treatment for Corina virus.

https://en.m.wikipedia.org/wiki/Hydroxychloroquine

https://www.beilstein-journals.org/bjoc/articles/14/45
https://www.ncbi.nlm.nih.gov/pubmed/29623120
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Harm Reduction Resources / Re: DIY Medical Tools to fight the Pandemic
« Last post by TangerineDream on March 20, 2020, 03:48:45 AM »
Depending on the resistance while breathing through it, maybe synthetic filter discs for mushroom growing could be useful?
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News / Re: tonne of e bust, korea to syd, tile adhesive
« Last post by maker on March 16, 2020, 07:09:24 PM »
Informative post.
Thank you.
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