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News / Re: Trip Begins Scientist uncover the molecular origins of an LSD trip
« Last post by TryItYoullLikeIt on September 21, 2020, 03:42:39 PM »
damn, Tsath writes a tome there haha
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News / Re: Trip Begins Scientist uncover the molecular origins of an LSD trip
« Last post by TryItYoullLikeIt on September 19, 2020, 03:16:49 PM »
Interesting
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News / Re: Trip Begins Scientist uncover the molecular origins of an LSD trip
« Last post by java on September 18, 2020, 03:37:54 PM »
25CN-NBOH (or NBOH-2C-CN) is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2014 by a group of researchers at the University of Copenhagen. This compound is notable as one of the most selective agonist ligands for the 5-HT2A receptor yet discovered, with a pKi of 8.88 at the human 5-HT2A receptor and with 100x selectivity for 5-HT2A over 5-HT2C, and 46x selectivity for 5-HT2A over 5-HT2B.[1][2][3][4] In animal studies, 25CN-NBOH was found to partially substitute for DOI but was considerably weaker at inducing a head-twitch response in mice.[5][6] Another in vivo evaluation of 25CN-NBOH concluded that "Given its distinct in vitro selectivity for 5-HT2A over non 5-HT2 receptors and its behavioral dynamics, 25CN-NBOH appears to be a powerful tool for dissection of receptor-specific cortical circuit dynamics, including 5-HT2A related psychoactivity."[7] Additional in vivo investigations with this ligand is emerging.[8][9] At tritiated version of 25CN-NBOH has also been accessed and used for more detailed investigations of the binding to 5-HT2 receptors and autoradiography.[10]


....see
  https://en.wikipedia.org/wiki/25CN-NBOH
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News / Re: Trip Begins Scientist uncover the molecular origins of an LSD trip
« Last post by TryItYoullLikeIt on September 18, 2020, 03:26:50 PM »
very nice...what's the common name of that 25 structure?
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News / Trip Begins Scientist uncover the molecular origins of an LSD trip
« Last post by java on September 18, 2020, 03:08:48 PM »
 Trip Begins Scientist uncover the molecular origins of an LSD trip

https://www.inverse.com/mind-body/how-lsd-binds-to-the-brain-study


Abstract:
 Hallucinogens like lysergic acid diethylamide (LSD), psilocybin, and substituted N-benzyl phenylalkylamines are widely used recreationally with psilocybin being considered as a therapeutic for many neuropsychiatric disorders including depression, anxiety, and substance abuse. How psychedelics mediate their actions— both therapeutic and hallucinogenic—are not understood, although activation of the 5-HT2A serotonin receptor (HTR2A) is key. To gain molecular insights into psychedelic actions, we determined the active-state struc- ture of HTR2A bound to 25-CN-NBOH—a prototypical hallucinogen—in complex with an engineered Gaq heterotrimer by cryoelectron microscopy (cryo-EM). We also obtained the X-ray crystal structures of HTR2A complexed with the arrestin-biased ligand LSD or the inverse agonist methiothepin. Comparisons of these structures reveal determinants responsible for HTR2A-Gaq protein interactions as well as the conformational rearrangements involved in active-state transitions. Given the potential therapeutic actions of hallucinogens, these findings could accelerate the discovery of more selective drugs for the treatment of a variety of neuropsychiatric disorders.





https://www.inverse.com/mind-body/how-lsd-binds-to-the-brain-study
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News / Re: LSD Chemist William Leonard Pickard to be Released From Prison
« Last post by hamsterbob on September 08, 2020, 04:24:54 AM »
I saw a report one of a dude spill 6000 trips of liquid on his hand no effects an the other of this dumb dude chasing his mate around his house with flakes on his finger after a spillage an he didnt get high.
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News / Re: LSD Chemist William Leonard Pickard to be Released From Prison
« Last post by Lipbalm on September 07, 2020, 10:42:34 PM »
From dosing tabs with crystal it is very easy for a little draft to pick a piece of xtal up and land on you doesn't take much to trip to be honest

Dr Nichols graduate students have said they have dipped their entire hands in LSD with no affects. The reports of dermal permeability seem to be all over the place. Maybe it is the difference between base and salt? I dunno, but I hear everyone in the drug community speak with the assumption, along with reports, that LSD is absorbed through skin and then I read LSD researchers and manufacturers say it isn't. My gut is they are both telling the truth somehow.
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News / Re: LSD Chemist William Leonard Pickard to be Released From Prison
« Last post by carl on September 07, 2020, 10:09:20 PM »
Pickard is a black hole.

My impression as well.
Looked like a fed honeypot from the start, if I would've been there I could tell immediately.
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News / Re: LSD Chemist William Leonard Pickard to be Released From Prison
« Last post by redred on September 07, 2020, 09:52:13 PM »
Pickard is a black hole.
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