Yes. Very true. Sorry bout that. I can't think anything stronger than hydrogen peroxide. Anyone know the oxidation state on perchloric acid & sodium perchlorate? And if perchloric acid isn't bad enough osmium tetroxide? This sounds like its going to explode. Suggestions on an appropriate oxidizing agent if that is of course the only problem with it?
Happyman
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Vesp
- Administrator
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I bet you could make the bromine derivative and then replace the bromine with flourine later.
I'm not sure how you'd do it, but that seems more practical to me then trying to get F2 - which literally burns water.
Perhaps HF would replace it producing HBr?
I doubt it... look at how other flurobenzenes are made.. that could help you out a lot.
I'm not sure how you'd do it, but that seems more practical to me then trying to get F2 - which literally burns water.
Perhaps HF would replace it producing HBr?
I doubt it... look at how other flurobenzenes are made.. that could help you out a lot.
Happyman
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You replied to that while I was on my way to delete it.
"An important aspect of this invention involves the reaction of a metal fluoride composition of the formula (AgF) (MF^, where M and x are as defined above, with chlorobenzene to produce fluorobenzene."
Metal fluoride heated with chlorobenze to produce fluorobenzene. DOC to DOF threw such a process?
Something starting from fluorobenzene but it would have trouble because of the electronegative-ness correct?
Fluorinated benzene manufacturing process
Munirpallam A. Subramanian
http://www.google.com/patents/about?id=JOgDAAAAEBAJ&dq=fluorination+benzene
"An important aspect of this invention involves the reaction of a metal fluoride composition of the formula (AgF) (MF^, where M and x are as defined above, with chlorobenzene to produce fluorobenzene."
Metal fluoride heated with chlorobenze to produce fluorobenzene. DOC to DOF threw such a process?
Something starting from fluorobenzene but it would have trouble because of the electronegative-ness correct?
Fluorinated benzene manufacturing process
Munirpallam A. Subramanian
http://www.google.com/patents/about?id=JOgDAAAAEBAJ&dq=fluorination+benzene
Douchermann
- Dominant Queen
- Posts: 397
Read the bioassays, then stop caring about fluoro derivatives of the dimethoxy's hahahaha
http://www.erowid.org/library/books_online/pihkal/pihkal026.shtml
No effects from 2C-F, and DOF is reported to be 4-6 times less potent than DOB and DOI.
http://www.erowid.org/library/books_online/pihkal/pihkal026.shtml
No effects from 2C-F, and DOF is reported to be 4-6 times less potent than DOB and DOI.
Happyman
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Did you go to Dave & Busters and leave your Fun in the car where it died of Heat Stroke? If I was the Indiana Jones of Chemistry you would not be my choice for a sidekick. Where's the Adventure? If you can chlorinate a aromatic rings then trade chlorine for fluorine without messin' with the groups 'round it that is what I'm about. Gas & Fluoridate is Happyman's master plan, but I wanna take this one step at a time.
Sedit
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Your idea of fun is lower potancy? If you where the travel adviser of chemistry I would not book my vacation with you, I would say I want fun and you would see if you can make it as dull as possible.
Me:" I want fun and adventure"
You: "Ok sir we have you booked with a time share seminar and then you will watch as other people play limbo all night"
Me:" I want fun and adventure"
You: "Ok sir we have you booked with a time share seminar and then you will watch as other people play limbo all night"
Happyman
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Haha, Well to quote Megatherium and rip a Hive Archive
"According to https://www.rhodium.ws/pdf/poos.aminorex-1.pdf the p-halogen analogs of aminorex are more powerfull than plain aminorex:
* aminorex: ED50 = 5.8 mg / kg
* p-bromo aminorex: ED50 = 4.6 mg / kg
* p-chloro aminorex: ED50 = 2.5 mg / kg
* p-fluoro aminorex: ED50 = 1.2 mg / kg"
Unfortunately that is the only one I have.
4-fluoroamphetamine gets good interesting reviews as an methamphetamine to MDMA intermediate. Intermediates could be very useful as replacement or gateway drugs for beginning users. Not 4-fluoroamphetamine in the USA though because that would be illegal under the analogue act, but possibly in another country where it is unregulated. 4-fluoromethamphetamine is also a Big Question Mark. Anyone got any bioassays?
We have the timeshare seminar where buy timeshares or we can send you to an undeveloped island searching for treasure.
And I apologize for walking the line.
"According to https://www.rhodium.ws/pdf/poos.aminorex-1.pdf the p-halogen analogs of aminorex are more powerfull than plain aminorex:
* aminorex: ED50 = 5.8 mg / kg
* p-bromo aminorex: ED50 = 4.6 mg / kg
* p-chloro aminorex: ED50 = 2.5 mg / kg
* p-fluoro aminorex: ED50 = 1.2 mg / kg"
Unfortunately that is the only one I have.
4-fluoroamphetamine gets good interesting reviews as an methamphetamine to MDMA intermediate. Intermediates could be very useful as replacement or gateway drugs for beginning users. Not 4-fluoroamphetamine in the USA though because that would be illegal under the analogue act, but possibly in another country where it is unregulated. 4-fluoromethamphetamine is also a Big Question Mark. Anyone got any bioassays?
We have the timeshare seminar where buy timeshares or we can send you to an undeveloped island searching for treasure.
And I apologize for walking the line.
2bfrank
- Guest
Hey all, Just wondering - say if someone wanted to reduce the unsaturated beta-nitrostyrene, and leaving the nitro intact. Is their a way to do this, other than yeast, which I think would do that well. I am not sure, I haven't done it, and of course its theoretical..
Thanks in advance
Also Been looking at the use of clay doped with metal nitrate, or ammonia nitrate in a domestic microwave oven..to produce the beta-nitrostyrene - yields aren't great - but not bad at a (60 - 70%), but considering elcheapo monomer and metal nitrate and time factor, it sort of looks good.. I haven't checked around though, so perhaps what I am stating is so all 90's stuff,, OH well. A bit of a slow learner perhaps
Ill attach it anyway.. and Douchemann, the para got sorted, 2/3 solid, 1/3 solution, conc sulfuric. I am still looking though..
2b
Thanks in advance
Also Been looking at the use of clay doped with metal nitrate, or ammonia nitrate in a domestic microwave oven..to produce the beta-nitrostyrene - yields aren't great - but not bad at a (60 - 70%), but considering elcheapo monomer and metal nitrate and time factor, it sort of looks good.. I haven't checked around though, so perhaps what I am stating is so all 90's stuff,, OH well. A bit of a slow learner perhaps
Ill attach it anyway.. and Douchemann, the para got sorted, 2/3 solid, 1/3 solution, conc sulfuric. I am still looking though..
2b
poisoninthestain
- Dominant Queen
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@2B-I think unless you were to protect the -NO2 function with some kind of alkyl group(just a farfetched guess probably not even close) then there's no way without reducing the nitro to an amine and the double pi bond to a single sigma bond which would yield phenethylamine.
It would be interesting if you found some way to protect the nitro. IIRC the nitro is already strongly deactivating to begin with.
It would be interesting if you found some way to protect the nitro. IIRC the nitro is already strongly deactivating to begin with.
2bfrank
- Guest
thanks poisoninthestain.. I have seen something like this, and cant find it.. Yeast would do it, I thought..It could of even been a type of Urushibara, Ill keep looking..
2b
Dont know where I was going with that, as yeast will reduce nitro groups in basic conditions, or so a couple or lit articles state. I have seen it somewhere, will keep looking..
2b
Dont know where I was going with that, as yeast will reduce nitro groups in basic conditions, or so a couple or lit articles state. I have seen it somewhere, will keep looking..
Happyman
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- Posts: 122
Threw the drugs-forums methcathinone from PPA via potassium dichromate came up but was shot down because that'd be cathinone. After that no one mentioned methylating it to methcathinone. Will that not work? I was going to ask them but after reading some of the other articles on that site I decide it best to come here.
Vesp
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I don't have any first hand experience or references but I know secondary alcohols can be oxidized into ketones, but the amine might also get oxidized into a nitro, nitrile, or something like that. If one were to use ephedrine, they could probably oxidize it to methcathinone, but I don't know how great the yeilds would be...
I'd like to know if that ketone can be transformed to just a hydrogen, reduced maybe with ZnHg/HCl. I don't know.
I'd like to know if that ketone can be transformed to just a hydrogen, reduced maybe with ZnHg/HCl. I don't know.
Happyman
- Subordinate Wasp
- Posts: 122
Two more questions. Benzoic acid from salicylic acid? Does this seem practical? I was thinking of acidifying sodium salicylate with hydrochloric to get benzoic acid, water and salt. 2nd question being asprin with sodium hydroxide gives you sodium acetate and salicylic acid right?
Vesp
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Sodium hydroxide with aspirin will produce the salts of the acids yes. salicylic acid is easily precipitated with the addition of acid, while acetic acid remains in solution, obviously.
Benzoic acid is not easy to get from salicylic acid, as you'd need to remove the phenol, OH, group. This is very difficult to do as far as I know. Your best bet is the oxidation of toluene with Mn persulfate, KMnO4, or probably some other nice oxidizers.
Benzoic acid is not easy to get from salicylic acid, as you'd need to remove the phenol, OH, group. This is very difficult to do as far as I know. Your best bet is the oxidation of toluene with Mn persulfate, KMnO4, or probably some other nice oxidizers.
2bfrank
- Guest
I have always wondered about this,, You read various extraction preps for eg, morphine type molecules, where they extract using CHCl3 most of the time.. I have always assumed that benzene or toluene would be okay for this, as long as the solvent was removed under vacuum, or just evaporrated somewhat naturally.. I dare say their is an optimal pH to get to, perhaps not to mess with the molecule, but just thought Id ask, in case someone knew about this.. Out of interest..
2b
2b
Bluebottle
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@Vesp:
Question: Can orthoborate esters R3BO3 be employed as N-alkylating agents? I've seen no references to this having been done successfully or even attempted, but I can't see why it wouldn't work. I do know that the adduct can be formed, the tendency possibly slowing the reaction, however under the proper conditions (higher heat, longer reaction time?) even a relatively low yield would be justifiable given borate esters damn easy production.
Quote
Is it really that simple? Seems way to easy, and so I'm skeptical of it.It's entirely untrue as you are likely aware. Page 88 of Advances in Heterocyclic Chemistry vol.3 states that cyclisation of tryptophan occurs even in alkaline conditions. However, there has been a reportedly simple synthesis of indole-3-acetaldehyde (essentially tryptophan and NaClO). This might then be reacted with the proper dialkylammonium formate, without quite so much risk of cyclisation (as far as I know); I have also seen reference to the reduction of imines with zinc dust/powder? in dilute NaOH - I don't know if that would work in this case being an iminium salt. Formic acid can of course be made from glycerol/oxalic acid. That would leave the dialkylamine to be reckoned with somehow...
You just mix and heat paraformaldehyde, with the hydrated form of oxalic acid, and tryptophan at 100*C for a few hours, to get the N,N-Dimethyl tryptophan, which can easily be decarboxylated to DMT. I always thought DMT was going to be way more difficult then that!
I don't think I am missing anything, but like I said, that is just to simple..so is there a catch?
Question: Can orthoborate esters R3BO3 be employed as N-alkylating agents? I've seen no references to this having been done successfully or even attempted, but I can't see why it wouldn't work. I do know that the adduct can be formed, the tendency possibly slowing the reaction, however under the proper conditions (higher heat, longer reaction time?) even a relatively low yield would be justifiable given borate esters damn easy production.
basstabone
- Pupae
- Posts: 50
Does anyone have the chart that has reduced pressure and temperature to tell what your vacuum is pulling at? I just set up my recirculating aspirator pump and tested it on water to make sure it was puklling a good vacuum. It was registering the temp at 45 degrees. Good vacuum?
~Bass
~Bass
Douchermann
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- Posts: 397
45C is about 120-125mm. The chart you are looking for is called a nomograph
http://chemistry.kenyon.edu/getzler/Research%20files/nomograph.gif
http://chemistry.kenyon.edu/getzler/Research%20files/nomograph.gif
basstabone
- Pupae
- Posts: 50
That was it! If no ice is used what would a water aspirator normally pull? I wasnt using vaseline or anything so I know that there were little holes where the vacuum was weak. Just making sure but at 0 degrees an aspirator can pull 14 mm of Hg right?
Douchermann
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If it's built right, maybe. I know a decent one can boil water at room temp (21C), which is about 40mm.