When forming a Grignard reagent from an alkyl halide and Mg, what keeps the newly formed reagent from just immediately reacting with other alkyl halide molecules to form di-alkyls?

I think you need a lewis acid.

I know that method. Even the diazotation of aniline and sandmeyer reaction is also on the list, but aniline is not so cheap. Instead of the lactic acid, so it would be preferred to use that...

No one said anything about aniline, which is aminobenzene. I'm talking about alanine, which is very cheap. Alanine is $30/kg. Exactly how are you going to get that thionyl chloride? It will be expensive any way you do it. Sandmeyer will be expensive and low yielding... so it is not on the list.

You'll know when the reaction is done if you follow it by TLC. You should do that the first time you run any rxn that you don't have experimental details on in order to optimize it. Just check in Vogel for a general procedure for the for the chlorination at each position, and reflux for the longer length of time.

ning
(acetaminophanatic)
04-16-04 22:15
No 501222

BTW, ning doesn't know if this has been done at the hive already, but you can knovenagel condense 3,4,5-TMB with acetonitrile as well as nitromethane. If the double-bond is reduced, then a hoffmann rearrangement will nicely yield a phenethylamine. Refs if desired.

Does anyone have said refs?

To make the acyl chloride of 2-chloropropionic acid, reflux S2Cl2 with a catalizing ammount of iodine. More info on the hive at a thread by antoncho on the making of acetic anhydride from sodium acetate and S2Cl2.

Thats right, you are going to add 28.0101g/mol

A good way to confirm if you are ever a bit unsure, look for known examples. For example; Anilines molecular weight compared to Benzamides, both are freely available at wiki.

A good way to do it is stop wasting time adding Carbon chains and draw the shit in ChemSketch and tell it to spit out the formula, weight, name....ect..ect... refractive index for that matter hell.

Point is Get ADC chemsketch and save yourself alot of time.

I would post an example but my image editor is all fucked up.

Split from Phenylalanine to amphetamine or N-methylamphetamine - Enkidu

I started thinking about routes from phenylalanine last night, and something occurred to me that for whatever reason I hadn't considered before.

Why can't we go from phenylalanine to phenylacetaldehyde via strecker degradation.. and then just oxidize it to phenylacetic acid and go from there?

I'm sure I'm missing something.

Java is right, I have actually talked about that method before (and still think it does have some merit). It is posted on the first page just so you dont have to go back here is the quote;

"Phenylalanine can be treated with nitrous acid to produce phenyllactic acid, nitrous acid is produced from sodium nitrite and any mineral acid. Phenyllactic acid can then be treated with Lead tetra acetate (made with red lead oxide and glacial acetic acid) and will yield around 58% phenylacetaldehyde.

http://www.journalarchive.jst.go.jp/jnlpdf.php?cdjournal=bcsj1926&cdvol=9&noissue=1&startpage=8&lang=en&from=jnlabstract

Strecker degradation of phenylalanine with sodium hypophosphite should return a better yield of phenylacetaldehyde than the procedure above.
Also alpha methylation of phenylalanine as previously discussed after strecker degradation yields phenylacetone.

http://www.erowid.org/archive/rhodium/chemistry/p2p.strecker.html

With phenylacetaldehyde in hand one would proceed to gas with methylamine to create the schiffs base, which could be dripped into methyl magnesium iodide to produce a modest (40%+) yield of racemic methamphetamine."

Yeh I argree I ran into this a while back but its still useful no doubt.

Any more details on the can?

I would evaporate the Et₂O or EtOH and see if there is any cinnamaldahyde present. There the possibility that the cinnamon oil is present in some kind of base formula for whatever application it has to aid in its use.

The fact that you say it has a defind melting point is interestin though to say the lest.

Piperidine is condensed with o-flouroaniline to produce the flouro substituted product, ocfentanil which is slightly more potent than its parent fentanyl. (if that helps?)

I think a valid target should be ohmefentany, it is easier to synth than carfentanyl but comparable in potency;

Ohmefentanyl (beta-hydroxy-3-methylfentanyl) is an extremely potent analgesic drug which selectively binds to the µ-opioid receptor.
Ohmefentanyl is one of the most potent u-receptor agonists known, comparable to super-potent opioids such as carfentanil and etorphine which are used for tranquilizing large animals such as elephants in veterinary medicine. In mouse studies, the most active isomer 3R,4S,?S-ohmefentanyl was 28 times more powerful as a painkiller than fentanyl, the chemical from which it is derived, and 6300 times more effective than morphine.[1]. Ohmefentanyl has three stereogenic centers and so has eight stereoisomers, which are named F9201-F9208. Researchers are studying the different pharmaceutical properties of these isomers.[2].
The 4"-fluoro analogue of the 3R,4S,?S isomer of ohmefentanyl is the most potent opioid yet discovered, possessing an analgesic potency approximately 18,000-fold greater than morphine.
from wiki.