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Author Topic: Short Questions Thread  (Read 10825 times)

Enkidu

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Re: Short Questions Thread
« Reply #720 on: January 13, 2011, 11:13:50 PM »
Yep.

akcom

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Re: Short Questions Thread
« Reply #721 on: January 14, 2011, 01:06:06 AM »

Helgoland

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Fentanyl-based opioid receptor antagonists
« Reply #722 on: January 21, 2011, 11:23:24 PM »
Are there any?

Helgland

Tsathoggua

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Re: Short Questions Thread
« Reply #723 on: January 22, 2011, 11:46:54 PM »
No idea, off the top of my head, but there is at least a partial agonist fent derivative that I can toss out there. Mirfentanil.
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I'm hyperbolic, hypergolic, viral, chiral. So motherfucking twisted my laevo is on the right side.

psychexplorer

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Re: Short Questions Thread
« Reply #724 on: January 23, 2011, 09:13:10 AM »
Quote from: akcom on January 13, 2011, 09:41:42 PM
Is platinum oxide a watched chemical?

Not on any list, and platinum and palladium are easily available OTC with five nines purity in the form of bullion.

Catalyst preparation will be extra work but should be nothing new.

Oerlikon

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Re: Short Questions Thread
« Reply #725 on: January 23, 2011, 09:02:35 PM »
When you have HOCH2CH2CH2CH2CHO (Hydroxyl group on one and aldehyde group o other) in acid media
you get lactol (a cyclic hemicacetal)

But what do you get when you have carboxylic acid group instead of aldehyde!?
For example HOCH2CH2CH2CH2COOH

(I don't care if it's possible,we are speaking about theory here.)
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Helgoland

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Re: Short Questions Thread
« Reply #726 on: January 24, 2011, 01:37:39 PM »
You might get a lactone:
hxxp://en.wikipedia.org/wiki/Lactone

Helgoland

Oerlikon

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Re: Short Questions Thread
« Reply #727 on: January 24, 2011, 04:02:53 PM »
Yes,you are right,thanks!
I found an answer later!
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RoidRage

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Re: Short Questions Thread
« Reply #728 on: January 31, 2011, 05:56:50 AM »
Is there any chance decomposition could occurs if I have a post-reaction Acidic Al/Hg containing a primary amine with a MD bridge mixture lying around for a few days? I'm a bit worried because of the low pH of the solution...In case you're wondering, I just don't have time to do the workup until a couple of days because of school...

Helgoland

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Re: Short Questions Thread
« Reply #729 on: January 31, 2011, 10:38:37 AM »
Is there a way to use aluminium for reductive amination without mercury? I didn't find anything on the net...

Helgoland

lugh

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A Short Answer
« Reply #730 on: January 31, 2011, 03:11:32 PM »
Quote
Is there a way to use aluminium for reductive amination without mercury? I didn't find anything on the net...

Helgoland

NO !!!!

 8)

Chemistry is our Covalent Bond

Oerlikon

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Re: Short Questions Thread
« Reply #731 on: January 31, 2011, 03:43:07 PM »
Quote from: lugh on January 31, 2011, 03:11:32 PM
Quote
Is there a way to use aluminium for reductive amination without mercury? I didn't find anything on the net...

Helgoland

NO !!!!

 8)



What about Galium and it's compounds!?
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akcom

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Re: Short Questions Thread
« Reply #732 on: January 31, 2011, 06:16:47 PM »
I think its clear the OP wants to make the process easier, not harder

Oerlikon

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Re: Short Questions Thread
« Reply #733 on: January 31, 2011, 06:28:32 PM »
Question is: Is it possible?
Definitely!

Is it easy!?
I don't know!
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salat

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Re: Short Questions Thread
« Reply #734 on: January 31, 2011, 08:51:51 PM »
http://en.wikipedia.org/wiki/Amalgam_(chemistry)

By definition in chemistry an amalgam is a combination involving mercury.

Salat
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NaBH4

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Re: Short Questions Thread
« Reply #735 on: January 31, 2011, 09:56:38 PM »
Aluminium in conc.Sodium hydroxide aqueous solution for making H2 gas ?  :D

I doubt bulling H2 gas in a Reductive Amination should be enough though...
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Oerlikon

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Re: Short Questions Thread
« Reply #736 on: January 31, 2011, 10:09:24 PM »
Quote from: salat on January 31, 2011, 08:51:51 PM
http://en.wikipedia.org/wiki/Amalgam_(chemistry)

By definition in chemistry an amalgam is a combination involving mercury.

Salat

He didn't mention amalgam,just reductive amination.
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Wizard X

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Re: Short Questions Thread
« Reply #737 on: February 01, 2011, 12:48:42 AM »
Al/Hg Amalgamation.

HgCl2 solutions are acidic and attack the Al2O3 surface oxide on the Al metal.
pH of 4.7 approx. Also reported a pH of 3.2 for a 0.2 M HgCl2 solution. (Ref. Merck 11th Ed. pg 924)

2Al + 3 HgCl2 ==> 2 AlCl3 (aq) + 3 Hg (solid)
2 AlCl3 (aq) + 3 H2O ==> Al2O3 + 6 HCl

This is why it's important to wash the AMALGAMATE, to remove any HgCl2 and HCl.

3 Hg deposits onto the freshly cleaned surface of Al forming greyish-black spots.

Al-Hg is Al dissolved in the Hg metal forming the amalgamation. Basically it can be written as such. [Al/Hg] <==> [Al(+3) + 3e / Hg]

Since Hg has high overvolts, and Al is more electrochemically reactive the "Dissolved Al" as [Al(+3) + 3e / Hg] reacts with water forming H2 and Al2O3 (hydrated form) at the surface site of Hg. This Hg surface site is were imines and H2 combine electrochemically.

Hg acts as a conductive medium, dissolving more Al(solid) and forming [Al(+3) + 3e / Hg] amalgamation as dissolved [Al(+3) + 3e] reacts with water.

Basic overall reaction: 2Al + 3 H2O ==> 3 H2 + Al2O3


Al(solid) ==> [Al(+3) + 3e / Hg] ==> 2 Al(+3) + 3e + 3 H2O ==> 3 H2 + Al2O3

In Vogel 5th Ed, pg 415-416, the aluminium surface is first cleaned with 10% sodium hydroxide solution so the amalgamation, 2Al + 3 HgCl2 ==> 2 AlCl3 (aq) + 3 Hg (solid) can proceed more efficiently to [Al/Hg] <==> [Al(+3) + 3e / Hg].


Catalytic Reductive Amination, H2 gas & catalyst. http://www.erowid.org/archive/rhodium/chemistry/reductive.amination.html
« Last Edit: February 01, 2011, 12:53:58 AM by Wizard X »
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salat

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Re: Short Questions Thread
« Reply #738 on: February 01, 2011, 01:13:47 AM »
Sorry bout that, I read it wrong.  Here's a section from a book covering reductive amination.
Duh
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pyramid

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Re: Short Questions Thread
« Reply #739 on: February 01, 2011, 03:47:46 AM »
What about NaCl/CuSO4? I believe someone at hyperlab had a success with that.
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